Author Archives: admin

Indossare i boxer piuttosto che gli slip, aiuta la fertilità maschile, GeneraRoma, Centri Genera, fertilità maschile
13 Ago
0

Indossare i boxer piuttosto che gli slip, aiuta la fertilità maschile

Indossare i boxer invece degli slip, aiuta la fertilità maschile. A rivelarlo è uno studio americano dell’Harvard TH Chan School of Public Health e del Fertility Clinic del Massachusetts General Hospital – pubblicato sulla rivista Human Reproduction – il quale ha ...

Read More
Fertilità femminile, tutti i vaccini utili per la donna in previsione e durante la gravidanza, GeneraRoma
10 Ago
0

Fertilità femminile: tutti i vaccini utili per la donna in previsione e durante la gravidanza

Fertilità femminile: tutti i vaccini utili per la donna in previsione e durante la gravidanza Il giorno 7 agosto 2018 il Ministero della  Salute ha emanato una circolare per la promozione della salute femminile in età fertile: un vademecum sulle ...

Read More
01 Ago
0

Fertilità: più informazione per far conoscere ai giovani i limiti della loro età riproduttiva. Intervento del Dr. Filippo Maria Ubaldi

Fertilità: più informazione per far conoscere ai giovani i limiti della loro età riproduttiva La probabilità di avere un bambino diminuisce con l’età. Tutti i ragazzi devono essere consapevoli, già durante gli anni scolastici, che il successo di una gravidanza ...

Read More
Largeur intervista alla Dr.ssa Laura Rienzi sulla tecnica della vitrificazione, crioconservazione ovociti
10 Lug
0

Su “Largeur” intervista alla Dr.ssa Laura Rienzi sulla tecnica di vitrificazione degli ovociti

Su “Largeur”  intervista alla Dr.ssa Laura Rienzi sulla tecnica di vitrificazione degli ovociti Su “Largeur” del 10 luglio l’intervista della Dr.ssa Laura Rienzi sulla tecnica di vitrificazione degli ovociti. Per leggere l’articolo clicca QUI

Read More
La celiachia non diagnosticata può causare problemi per le donne che provano ad avere un bambino, Genera Roma
10 Lug
0

La celiachia non diagnosticata può causare problemi per le donne che provano ad avere un bambino

La celiachia non diagnosticata può causare problemi per le donne che provano ad avere un bambino Le donne con celiachia non diagnosticata hanno una probabilità maggiore di andare incontro ad aborti spontanei o morte fetale. Lo ha dimostrato uno studio ...

Read More
Su “Technologist” “Cryopreservation: a new miracle?” Intervista alla Dr.ssa Laura Rienzi
09 Lug
0

Su “Technologist” “Cryopreservation: a new miracle?” Intervista alla Dr.ssa Laura Rienzi

Su “Technologist” “Cryopreservation: a new miracle?” Intervista alla Dr.ssa Laura Rienzi   Su “Technologist” “Cryopreservation: a new miracle?” Women who want to delay their pregnancies can now freeze their eggs effectively and safely. But success is not guaranteed. Intervista alla ...

Read More
Education program in Reproduction and Development, Monash University, Prato 7-8 luglio 2018, Dr.ssa Laura Rienzi
07 Lug
0

Education Program in Reproduction and Development- 30th Anniversary Symposium- Monash University Prato 7-8 luglio 2018. Tra i relatori la Dr.ssa Laura Rienzi

Education Program in Reproduction and Development- 30th Anniversary Symposium- Monash University Prato 7-8 luglio 2018 Si sta svolgendo alla Monash University di Prato,  l'”Education Program in Reproduction and Development- 30th Anniversary Symposium”. Domani interverrà la Dr.ssa Laura Rienzi con una relazione ...

Read More
Eshre 2018 Annual meeting European Society of Human Reproduction and Embryology – ESHRE, Barcellona 1-4 luglio 2018
02 Lug
0

Annual meeting European Society of Human Reproduction and Embryology – ESHRE, Barcellona 1-4 luglio 2018

All'”Annual meeting European Society of Human Reproduction and Embryology – ESHRE“, che si è svolto a Barcellona dall’1 al 4 luglio 2018, ha partecipato numerosa l’equipe dei Centri GENERA. Il Dr. Danilo Cimadomo ha discusso il poster dal titolo “Euploid ...

Read More
Preservazione della fertilità: primo passo verso l’ovaio artificiale umano, Congresso ESHERE, GeneraRoma
02 Lug
0

Preservazione della fertilità: primo passo verso l’ovaio artificiale umano    

Preservazione della fertilità: primo passo verso l’ovaio artificiale umano L’ovaio artificiale umano è quasi una realtà: Il risultato è stato ottenuto dal Laboratorio di Biologia riproduttiva del Rigshospitalet di Copenhagen e presentato al congresso della Società Europea di Riproduzione Umana ...

Read More
Abstract STUDY QUESTION Are the mean numbers of blastocysts obtained from sibling cohorts of oocytes recruited after follicular phase and luteal phase stimulations (FPS and LPS) in the same ovarian cycle similar? SUMMARY ANSWER The cohorts of oocytes obtained after LPS are larger than their paired-FPS-derived cohorts and show a comparable competence, thus resulting in a larger mean number of blastocysts. WHAT IS KNOWN ALREADY Three theories of follicle recruitment have been postulated to date: (i) the ‘continuous recruitment’ theory, (ii) the ‘single recruitment episode’ theory and (iii) the ‘wave’ theory. Yet, a clear characterization of this crucial biological process for human reproduction is missing. Recent advances implemented in in vitro fertilization (IVF), such as blastocyst culture, aneuploidy testing and vitrification, have encouraged clinicians to maximize the exploitation of the ovarian reserve through tailored stimulation protocols, which is crucial especially for poor prognosis patients aiming to conceive after IVF. LPS has been already successfully adopted to treat poor prognosis or oncological patients through Duostim, LPS-only or random-start ovarian stimulation approaches. Nevertheless, little, and mainly retrospective, evidence has been produced to support the safety of LPS in general. Feasibility of the LPS approach would severely question the classic ‘single recruitment episode’ theory of follicular development. STUDY DESIGN, SIZE, DURATION This case-control study was conducted with paired follicular phase- and luteal phase-derived cohorts of oocytes collected after stimulations in the same ovarian cycle (DuoStim) at two private IVF clinics between October 2015 and December 2017. PARTICIPANTS/MATERIALS, SETTING, METHODS The study included 188 poor prognosis patients undergoing DuoStim with preimplantation genetic testing for aneuploidies (PGT-A). FPS and LPS were performed with the same daily dose of recombinant-gonadotrophins in an antagonist protocol. Blastocyst culture, trophectoderm biopsy, vitrification and frozen-warmed euploid single blastocyst transfers were performed. The primary outcome was the mean number of blastocysts obtained per oocyte retrieval from paired-FPS- and LPS-derived cohorts (required sample size = 165 patients; power = 90%). Mean blastulation and euploidy rates were monitored, along with the number of oocytes, euploid blastocysts and clinical outcomes. MAIN RESULTS AND THE ROLE OF CHANCE Significantly fewer blastocysts were obtained after FPS than LPS (1.2 ± 1.1 vs. 1.6 ± 1.6, P < 0.01), due to fewer oocytes collected (3.6 ± 2.1 vs. 4.3 ± 2.8, P < 0.01) and a similar mean blastocyst rates per retrieval (33.1% ± 30.3% vs. 37.4% ± 30.8%, P = NS). The number of oocytes collected were correlated (R = 0.5, P < 0.01), while the blastocyst rates were uncorrelated among paired-FPS- and LPS-derived cohorts. Overall, a significantly lower chance of producing blastocyst(s) was reported after FPS than after LPS: 67.6% (n = 127/188, 95%CI: 60.3–74.1) vs. 77.1% (n = 145/188, 95%CI: 70.3–82.8; P = 0.05). The mean euploidy rates per retrieval were similar between FPS- and LPS-derived cohorts of oocytes (13.6% ± 22.8% vs. 16.3% ± 23.4%, P = NS). Therefore, on average fewer euploid blastocysts (0.5 ± 0.8 vs. 0.7 ± 1.0, P = 0.02) resulted from FPS. Similar ongoing-pregnancy/delivery rates were reported, to date, after FPS- and LPS-derived euploid single blastocyst transfers: 42.4% (n = 28/66, 95%CI: 30.5–55.2) vs. 53.8% (n = 35/65, 95%CI: 41.1–66.1; P = NS). LIMITATIONS, REASONS FOR CAUTION More studies need to be conducted in the future to confirm the safety of LPS, especially in terms of ovarian and follicular environment, as well as the clinical, peri-natal and post-natal outcomes. Here, we showed preliminary data suggesting a similar ongoing implantation/delivery rate (>22 weeks) between FPS- and LPS-derived euploid blastocysts, that need to be extended in the future, to populations other than poor prognosis patients and using approaches other than DuoStim together with a constant monitoring of the related peri-natal and post-natal outcomes. WIDER IMPLICATIONS OF THE FINDINGS These data, from a paired study design, highlight that LPS-derived oocytes are as competent as FPS-derived oocytes, thereby adding some evidence to support the use of LPS for poor prognosis and oncological patients and to question the ‘single recruitment episode’ theory of follicle recruitment. These findings also encourage additional studies of the basics of folliculogenesis, with direct clinical implications for the management of ovarian stimulation in IVF. TRIAL REGISTRATION None. STUDY FUNDING/COMPETING INTEREST(S) No external funds were used for this study and there are no conflicts of interest. oocyte competence, luteal phase, DuoStim, blastocyst, ovarian stimulation, follicle recruitment, Dr Filippo Maria Ubaldi, Laura Rienzi, Danilo Cimadomo
21 Giu
0

Human Reproduction: Luteal phase anovulatory follicles result in the production of competent oocytes: intra-patient paired case-control study comparing follicular versus luteal phase stimulations in the same ovarian cycle

Human Reproduction: Luteal phase anovulatory follicles result in the production of competent oocytes: intra-patient paired case-control study comparing follicular versus luteal phase stimulations in the same ovarian cycle Danilo Cimadomo, Alberto Vaiarelli, Silvia Colamaria, Elisabetta Trabucco,Carlo Alviggi, Roberta Venturella, Erminia Alviggi, Ramona Carmelo, Laura Rienzi, Filippo Maria Ubaldi ...

Read More