Intrauterine insemination is the simplest technique of ART.
For the execution of IUI, the seminal fluid, properly prepared in the laboratory, is deposited in the uterine cavity with a special catheter, in order to increase the density of gametes in the site where the fertilization takes place in vivo.
IUI is indicated in the following cases:
- idiopathic infertility
- psychological factor
- erectile dysfunction
- retrograde ejaculation
- mild male factor
- mild and moderate endometriosis
- immunological cause
- serodiscordant couples (e.g. male partners carrying a viral disease) in which a pre-treatment seminal fluid wash is indicated
- patient’s willingness (in case of ethical and religious objections to IVF)
- donation of male gametes for male partner sterility
- decision of the specialist according to the specific clinical case
For intrauterine insemination, however, the absence of structural impediments at the tubal levelis necessary.
INTRAUTERINE INSEMINATION: STEPS
BASAL ULTRASOUND EVALUATION
Transvaginal ultrasound to be performed by day 3 of the menstrual cycle to assess the basal status of the ovaries.
SERIAL EVALUATION OF FOLLICOLAR GROWTH
Serial ultrasound evaluation of spontaneous monofollicular growth (spontaneous cycle IUI) or stimulated by taking follicular growth-inducing drugs for a period varying between 7 and 15 days(stimulated cycle IUI).
Administration of hCG (Human Chorionic Gonadotropin) for ovulation induction, once one or twofollicles with a diameter greater than 17-18mm are displayed.
SPERM PREPARATION IN THE LAB
Collection, washing and preparation of semen in the laboratory.
INTRAUTERINE INSEMINATION (IUI)
Transfer of the processed seminal fluid into the uterus by trans-cervical catheter.
LUTEAL PHASE SUPPORT AND PREGNANCY TESTING
Luteal phase support and serum beta-hCG dosage (14 days after insemination).