Pubblicazioni

PUBBLICAZIONI

La qualità scientifica del nostro gruppo ha portato alla pubblicazione di oltre 250 articoli su riviste scientifiche internazionali.

“Si cura meglio dove si fa ricerca”.

Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial

Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial Antonio Capalbo, Maurizio Poli, Laura Rienzi, Laura Girardi, Cristina Patassini, Marco Fabiani, Danilo Cimadomo, Francesca Benini, Alessio Farcomeni, Juliana Cuzzi, Carmen Rubio, Elena Albani, Laura Sacchi, Alberto Vaiarelli, Matteo Figliuzzi, Necati Findikli, Onder Coban, Fazilet K. Boynukalin, Ivan Vogel, Eva Hoffmann, Claudia Livi, Paolo E. Levi-Setti, Filippo M. Ubaldi, and Carlos Simo AJHG November 18, 2021DOI:https://doi.org/10.1016/j.ajhg.2021.11.002 Summary Chromosome imbalance (aneuploidy) is the major cause of pregnancy loss and congenital disorders in humans. Analyses of small biopsies from human embryos suggest that aneuploidy commonly originates during early

Clinical, obstetric and perinatal outcomes after vitrified-warmed euploid blastocyst transfer are independent of cryo-storage duration

Clinical, obstetric and perinatal outcomes after vitrified-warmed euploid blastocyst transfer are independent of cryo-storage duration Danilo Cimadomo, Gemma Fabozzi, Lisa Dovere, Roberta Maggiulli, Laura Albricci, Federica Innocenti, Daria Soscia, Adriano Giancani, Alberto Vaiarelli, Maurizio Guido, Filippo Maria Ubaldi, Laura Rienzi RBMO October 07, 2021DOI:https://doi.org/10.1016/j.rbmo.2021.09.027 Abstract Research question The study aimed to retrospectively evaluate the impact of cryo-storage duration on clinical, obstetric and perinatal outcomes after vitrified-warmed euploid blastocyst transfer. Design This was an observational study including 2688 vitrified-warmed euploid single blastocyst transfers that was conducted at a private IVF centre between May 2013 and March 2020. It included a total

Inter-centre reliability in embryo grading across several IVF clinics is limited: implications for embryo selection

Inter-centre reliability in embryo grading across several IVF clinics is limited: implications for embryo selection Danilo Cimadomo, Laura Sosa Fernandez, Daria Soscia, Gemma Fabozzi, Francesca Benini, Amalia Cesana, Maria Beatrice Dal Canto, Roberta Maggiulli, Saverio Muzzì, Catello Scarica, Laura Rienzi, Lucia De Santis RBMO October 06, 2021DOI:https://doi.org/10.1016/j.rbmo.2021.09.022 Abstract Research question What is the intra- and inter-centre reliability in embryo grading performed according to the Istanbul Consensus across several IVF clinics? Design Forty Day 3 embryos and 40 blastocysts were photographed on three focal planes. Senior and junior embryologists from 65 clinics were invited to grade them according to the Istanbul

Measuring success in IVF is a complex multidisciplinary task: time for a consensus?

Measuring success in IVF is a complex multidisciplinary task: time for a consensus? Laura Rienzi, Danilo Cimadomo, Alberto Vaiarelli, Gianluca Gennarelli, Jan Holte, Claudia Livi, Monica Aura Masip, Petr Uher, Gemma Fabozzi, Filippo Maria Ubaldi RBMO Reproductive BioMedicine, online 20 August 2021, https://doi.org/10.1016/j.rbmo.2021.08.012 ABSTRACT The goal of an IVF cycle is the birth of at least one baby per intention to treat. However, IVF cannot confer competence on an embryo, but only can provide each couple with a safe treatment to meet a predetermined chance of success. This commentary highlights how clinical, financial and patient-centred perspectives should be included in

Maternal body mass index associates with blastocyst euploidy and live birth rates: the tip of an iceberg?

Maternal body mass index associates with blastocyst euploidy and live birth rates: the tip of an iceberg? Gemma Fabozzi, Danilo Cimadomo, Mariachiara Allori, Alberto Vaiarelli, Silvia Colamaria, Cindy Argento, Maria Giulia Amendola, Federica Innocenti, Daria Soscia, Roberta Maggiulli, Rossella Mazzilli, Nicolò Ubaldi, Benedetta Iussig, Marco Marchetti, Laura Rienzi, Filippo Maria Ubaldi RBMO Reproductive Biomedicine Published:July 22, 2021DOI:https://doi.org/10.1016/j.rbmo.2021.07.006 Abstract Research question: Does maternal preconceptional body mass index (BMI) associate with mean blastocyst euploidy rate (m-ER) per patient and live birth rate (LBR) after vitrified–warmed euploid single embryo transfer (SET)? Design: Observational study conducted between April 2013 and March 2020 at a private

Severe male factor in in vitro fertilization- definition, prevalence, and treatment. An update

Rossella Mazzilli, Alberto Vaiarelli, Lisa Dovere, Danilo Cimadomo, Nicolò Ubaldi, Susanna Ferrero, Laura Rienzi, Francesco Lombardo, Andrea Lenzi, Herman Tournaye, Filippo Maria Ubaldi Asian Journal of Andrology 2021 Jul 6.; doi: 10.4103/aja.aja_53_21; Abstract Infertility affects 10%–15% of couples worldwide. Of all infertility cases, 20%–70% are due to male factors. In the past, men with severe male factor (SMF) were considered sterile. Nevertheless, the development of intracytoplasmic sperm injection (ICSI) drastically modified this scenario. The advances in assisted reproductive technology (ART), specifically regarding surgical sperm retrieval procedures, allowed the efficacious treatment of these conditions. Yet, before undergoing ICSI, male factor infertility

Educational needs of fertility healthcare professionals using ART: a multi-country mixed-methods study

Educational needs of fertility healthcare professionals using ART: a multi-country mixed-methods study Sophie Péloquin, Juan A. Garcia-Velasco, Christophe Blockeel, Laura Rienzi, Guy de Mesmaeker, Patrice Lazure, Fabiola Beligotti, Suzanne Murray RBMO Reproductive BioMedicine   online 2 July 2021, https://doi.org/10.1016/j.rbmo.2021.06.020   ABSTRACT Research question: What are the most pressing educational needs of fertility healthcare professionals using assisted reproductive technologies (ART)? Design: This mixed-methods study combined qualitative interviews with quantitative surveys. Participants included physicians and nurses specialized in reproductive endocrinology or in obstetrics/gynaecology, and laboratory specialists, with a minimum of 3 years of experience, practising in Australia, Brazil, Canada, China, France, Germany, India,

Fertilization rate as a novel indicator for cumulative live birth rate: a multicenter retrospective cohort study of 9,394 complete in vitro fertilization cycles

Fertilization rate as a novel indicator for cumulative live birth rate: a multicenter retrospective cohort study of 9,394 complete in vitro fertilization cycles Giulia Scaravelli, Carlotta Zacà, Paolo Emanuele Levi Setti, Claudia Livi, Filippo Maria Ubaldi, Maria Teresa Villani, Ermanno Greco, Maria Elisabetta Coccia, Alberto Revelli, Giuseppe Ricci, Francesco Fusi, Vincenzo Vigiliano, Roberto De Luca, Simone Bolli, Andrea Borini Fertility and Sterility – Published:May 07, 2021DOI:https://doi.org/10.1016/j.fertnstert.2021.04.006 Objective: To appraise the fertilization rate as a predictive factor for cumulative live birth rate (CLBR). Design: Multicenter retrospective cohort study. Setting: Ten in vitro fertilization clinics, whose data were collected and processed by the assisted reproductive technology (ART)

In vitro fertilization and andrology laboratory in 2030: expert visions

In vitro fertilization and andrology laboratory in 2030: expert visions Alison Campbell, David K Gardner, Marcos Meseguer, Kathleen A Miller, Markus Montag, Gianpiero D Palermo, Stephanie Cheung, Derek Keating, Philip Xie, Zev Rosenwaks, Laura Rienzi, Federica Innocenti, Danilo Cimadomo, Filippo Maria Ubaldi, Denny Sakkas, Michael J Tucker, Liesl Nel Themaat, Carlos Simon Fertility and Sterility Volume 116, Issue 1, July 2021, Pages 4-12  https://doi.org/10.1016/j.fertnstert.2021.05.088 Abstract The aim of this article is to gather 9 thought leaders and their team members to present their ideas about the future of in vitro fertilization and the andrology laboratory. Although we have seen much progress and innovation in the laboratory over the years, there is still much to come, and this