Pubblicazioni

PUBBLICAZIONI

La qualità scientifica del nostro gruppo ha portato alla pubblicazione di oltre 200 articoli su riviste scientifiche internazionali.

“Si cura meglio dove si fa ricerca”.

Clinical validity and utility of preconception expanded carrier screening for the management of reproductive genetic risk in IVF and general population

Clinical validity and utility of preconception expanded carrier screening for the management of reproductive genetic risk in IVF and general population A. Capalbo, M. Fabiani, S. Caroselli, M. Poli, L. Girardi, C. Patassini, F. Favero, D. Cimadomo, A. Vaiarelli, C. Simon, L. F. Rienzi, F. M. Ubaldi Human Reproduction, deab 087, https://doi.org/10.1093/humrep/deab087 Published: 22 May 2021 Abstract STUDY QUESTION What is the clinical validity and utility of preconception Expanded Carrier Screening (ECS) application on the management of prospective parents? SUMMARY ANSWER The high detection rate of at-risk couples (ARCs) and the high proportion opting for IVF/preimplantation genetic testing (PGT) treatment demonstrate the clinical utility of ECS in the preconception space

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives Roberta Maggiulli, Alberto Vaiarelli, Danilo Cimadomo, Adriano Giancani , Luisa Tacconi, Gemma Fabozzi, Filippo Maria Ubaldi, Laura Rienzi Jove April 28, 2021,  doi:10.3791/61963 (2021)  jove.com/t/61963 Abstract Preserving female fertility is crucial in a multifunctional healthcare system that takes care of patients’ future quality of life. Oocyte cryopreservation is recognized by several international scientific societies as the gold standard for fertility preservation in postpubertal women, for both medical and non-medical indications. The main medical indications are oncologic diseases, gynecologic diseases such as severe endometriosis, systemic diseases compromising the ovarian reserve, and genetic

Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines

Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines Sandro C. Esteves, Alessandro Conforti, Sesh, Sunkara, Luigi Carbone, Silvia Picarelli, Alberto Vaiarelli, Danilo Cimadomo, Laura Rienzi, Filippo Maria Ubaldi, Fulvio Zullo, Claus Yding Andersen, Raoul Orvieto, Peter Humaidan, and Carlo Alviggi Frontiers in Endocrinology – published: 19 March 2021 doi: 10.3389/fendo.2021.587051 Abstract The POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) criteria were developed to help clinicians identify and classify low-prognosis patients undergoing assisted reproductive technology (ART) and provide guidance for possible therapeutic strategies to overcome infertility. Since its introduction, the number of published studies using the POSEIDON criteria has increased steadily. However,

Oocyte competence is independent of the ovulation trigger adopted: a large observational study in a setting that entails vitrified-warmed single euploid blastocyst transfer

Oocyte competence is independent of the ovulation trigger adopted: a large observational study in a setting that entails vitrified-warmed single euploid blastocyst transfer Danilo Cimadomo, Alberto Vaiarelli, Cecilia Petriglia, Gemma Fabozzi, Susanna Ferrero, Mauro Schimberni, Cindy Argento, Silvia Colamaria, Maddalena Giuliani, Nicolò Ubaldi, Laura Rienzi & Filippo Maria Ubaldi  Journal of Assisted Reproduction and Genetics, Published: 04 March 2021 Abstract Purpose: To assess whether the GnRH-agonist or urinary-hCG ovulation triggers affect oocyte competence in a setting entailing vitrified-warmed euploid blastocyst transfer. Methods: Observational study (April 2013–July 2018) including 2104 patients (1015 and 1089 in the GnRH-a and u-hCG group, respectively) collecting ≥1 cumulus-oocyte-complex (COC) and undergoing ICSI with ejaculated sperm, blastocyst culture, trophectoderm

Is it in our patients’ blood? On a quest for predictors of blastocysts’ aneuploidy rate

Is it in our patients’ blood? On a quest for predictors of blastocysts’ aneuploidy rate Danilo Cimadomo, Laura Rienzi, Filippo Maria Ubaldi Fertility and Sterility Published:February 26, 2021 DOI:https://doi.org/10.1016/j.fertnstert.2021.02.013 Abstract Reflections on “Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization” by Hanson et al.

Leave the past behind: women's reproductive history shows no association with blastocysts' euploidy and limited association with live birth rates after euploid embryo transfers

Leave the past behind: women’s reproductive history shows no association with blastocysts’ euploidy and limited association with live birth rates after euploid embryo transfers Danilo Cimadomo, Antonio Capalbo, Lisa Dovere, Luisa Tacconi, Daria Soscia, Adriano Giancani, Emiliano Scepi, Roberta Maggiulli, Alberto Vaiarelli, Laura Rienzi, Filippo Maria Ubaldi Human Reproduction, pp. 1-12, 2021 Feb 20; deab 014. doi: 10.1093/humrep/deab014  Abstract STUDY QUESTION: Is there an association between patients’ reproductive history and the mean euploidy rates per biopsied blastocysts (m-ER) or the live birth rates (LBRs) per first single vitrified-warmed euploid blastocyst transfers? SUMMARY ANSWER: Patients’ reproductive history (as annotated during counselling) showed no association with the m-ER, but a lower LBR

The Impact of Unbalanced Maternal Nutritional Intakes on Oocyte Mitochondrial Activity: Implications for Reproductive Function

  The Impact of Unbalanced Maternal Nutritional Intakes on Oocyte Mitochondrial Activity: Implications for Reproductive Function Gemma Fabozzi, Benedetta Iussig, Danilo Cimadomo, Alberto Vaiarelli, Roberta Maggiulli, Nicolò Ubaldi, Filippo Maria Ubaldi and Laura Rienzi Antioxidants 2021, 10, 91. https://doi.org/ 10.3390/antiox10010091 – Received: 30 November 2020 Accepted: 7 January 2021 Published: 11 January 2021 Abstract Accumulating evidence on the effect of nutrition on reproduction is emerging from both animal and human studies. A healthy dietary pattern and nutrient supplementation, especially during the peri-conceptional period, might be helpful to achieve a live birth, although the mechanisms implicated are not fully understood. The

Practical Clinical and Diagnostic Pathway for the Investigation of the Infertile Couple

Practical Clinical and Diagnostic Pathway for the Investigation of the Infertile Couple Andrea Garolla, Damiano Pizzol, Andrea Roberto Carosso, Andrea Borini, Filippo Maria Ubaldi, Aldo Eugenio Calogero, Alberto Ferlin, Antonio Lanzone, Francesco Tomei, Bruno Eng, Laura Rienzi, Lucia De Santis, Giovanni Coticchio, Lee Smith, Rossella Cannarella, Attilio Anastasi, Massimo Menegazzo, Liborio Stuppia, Christian Corsini, Carlo Foresta Frontiers in Endocrinology, 19 January 2021 | https://doi.org/10.3389/fendo.2020.591837