Measuring success in IVF is a complex multidisciplinary task: time for a consensus? Laura Rienzi, Danilo Cimadomo, Alberto Vaiarelli, Gianluca Gennarelli, Jan Holte, Claudia Livi, Monica Aura Masip, Petr Uher, Gemma Fabozzi, Filippo Maria Ubaldi RBMO Reproductive BioMedicine, online 20 August 2021, https://doi.org/10.1016/j.rbmo.2021.08.012 ABSTRACT The goal of an IVF cycle is the birth of at least one baby per intention to treat. However, IVF cannot confer competence on an embryo, but only can provide each couple with a safe treatment to meet a predetermined chance of success. This commentary highlights how clinical, financial and patient-centred perspectives should be included in
La qualità scientifica del nostro gruppo ha portato alla pubblicazione di oltre 200 articoli su riviste scientifiche internazionali.
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Maternal body mass index associates with blastocyst euploidy and live birth rates: the tip of an iceberg?
Maternal body mass index associates with blastocyst euploidy and live birth rates: the tip of an iceberg? Gemma Fabozzi, Danilo Cimadomo, Mariachiara Allori, Alberto Vaiarelli, Silvia Colamaria, Cindy Argento, Maria Giulia Amendola, Federica Innocenti, Daria Soscia, Roberta Maggiulli, Rossella Mazzilli, Nicolò Ubaldi, Benedetta Iussig, Marco Marchetti, Laura Rienzi, Filippo Maria Ubaldi RBMO Reproductive Biomedicine Published:July 22, 2021DOI:https://doi.org/10.1016/j.rbmo.2021.07.006 Abstract Research question: Does maternal preconceptional body mass index (BMI) associate with mean blastocyst euploidy rate (m-ER) per patient and live birth rate (LBR) after vitrified–warmed euploid single embryo transfer (SET)? Design: Observational study conducted between April 2013 and March 2020 at a private
Rossella Mazzilli, Alberto Vaiarelli, Lisa Dovere, Danilo Cimadomo, Nicolò Ubaldi, Susanna Ferrero, Laura Rienzi, Francesco Lombardo, Andrea Lenzi, Herman Tournaye, Filippo Maria Ubaldi Asian Journal of Andrology 2021 Jul 6.; doi: 10.4103/aja.aja_53_21; Abstract Infertility affects 10%–15% of couples worldwide. Of all infertility cases, 20%–70% are due to male factors. In the past, men with severe male factor (SMF) were considered sterile. Nevertheless, the development of intracytoplasmic sperm injection (ICSI) drastically modified this scenario. The advances in assisted reproductive technology (ART), specifically regarding surgical sperm retrieval procedures, allowed the efficacious treatment of these conditions. Yet, before undergoing ICSI, male factor infertility
Educational needs of fertility healthcare professionals using ART: a multi-country mixed-methods study
Educational needs of fertility healthcare professionals using ART: a multi-country mixed-methods study Sophie Péloquin, Juan A. Garcia-Velasco, Christophe Blockeel, Laura Rienzi, Guy de Mesmaeker, Patrice Lazure, Fabiola Beligotti, Suzanne Murray RBMO Reproductive BioMedicine online 2 July 2021, https://doi.org/10.1016/j.rbmo.2021.06.020 ABSTRACT Research question: What are the most pressing educational needs of fertility healthcare professionals using assisted reproductive technologies (ART)? Design: This mixed-methods study combined qualitative interviews with quantitative surveys. Participants included physicians and nurses specialized in reproductive endocrinology or in obstetrics/gynaecology, and laboratory specialists, with a minimum of 3 years of experience, practising in Australia, Brazil, Canada, China, France, Germany, India,
Fertilization rate as a novel indicator for cumulative live birth rate: a multicenter retrospective cohort study of 9,394 complete in vitro fertilization cycles
Fertilization rate as a novel indicator for cumulative live birth rate: a multicenter retrospective cohort study of 9,394 complete in vitro fertilization cycles Giulia Scaravelli, Carlotta Zacà, Paolo Emanuele Levi Setti, Claudia Livi, Filippo Maria Ubaldi, Maria Teresa Villani, Ermanno Greco, Maria Elisabetta Coccia, Alberto Revelli, Giuseppe Ricci, Francesco Fusi, Vincenzo Vigiliano, Roberto De Luca, Simone Bolli, Andrea Borini Fertility and Sterility – Published:May 07, 2021DOI:https://doi.org/10.1016/j.fertnstert.2021.04.006 Objective: To appraise the fertilization rate as a predictive factor for cumulative live birth rate (CLBR). Design: Multicenter retrospective cohort study. Setting: Ten in vitro fertilization clinics, whose data were collected and processed by the assisted reproductive technology (ART)
In vitro fertilization and andrology laboratory in 2030: expert visions Alison Campbell, David K Gardner, Marcos Meseguer, Kathleen A Miller, Markus Montag, Gianpiero D Palermo, Stephanie Cheung, Derek Keating, Philip Xie, Zev Rosenwaks, Laura Rienzi, Federica Innocenti, Danilo Cimadomo, Filippo Maria Ubaldi, Denny Sakkas, Michael J Tucker, Liesl Nel Themaat, Carlos Simon Fertility and Sterility Volume 116, Issue 1, July 2021, Pages 4-12 https://doi.org/10.1016/j.fertnstert.2021.05.088 Abstract The aim of this article is to gather 9 thought leaders and their team members to present their ideas about the future of in vitro fertilization and the andrology laboratory. Although we have seen much progress and innovation in the laboratory over the years, there is still much to come, and this
Recombinant human luteinizing hormone co-treatment in ovarian stimulation for assisted reproductive technology in women of advanced reproductive age: a systematic review and meta-analysis of randomized controlled trials
Recombinant human luteinizing hormone co-treatment in ovarian stimulation for assisted reproductive technology in women of advanced reproductive age: a systematic review and meta-analysis of randomized controlled trials Alessandro Conforti, Sandro C. Esteves, Peter Humaidan, Salvatore Longobardi, Thomas D’Hooghe, Raoul Orvieto, Alberto Vaiarelli, Danilo Cimadomo, Laura Rienzi, Filippo Maria Ubaldi, Fulvio Zullo and Carlo Alviggi Reproductive Biology and Endocrinology https://doi.org/10.1186/s12958-021-00759-4 – Published: 21 June 2021 Abstract Introduction: Several studies suggest that luteinizing hormone (LH) could improve IVF outcome in women of advanced reproductive age by optimizing androgen production. In this review, we assessed the role of recombinant-human LH (r-hLH) and recombinant
Clinical validity and utility of preconception expanded carrier screening for the management of reproductive genetic risk in IVF and general population
Clinical validity and utility of preconception expanded carrier screening for the management of reproductive genetic risk in IVF and general population A. Capalbo, M. Fabiani, S. Caroselli, M. Poli, L. Girardi, C. Patassini, F. Favero, D. Cimadomo, A. Vaiarelli, C. Simon, L. F. Rienzi, F. M. Ubaldi Human Reproduction, deab 087, https://doi.org/10.1093/humrep/deab087 Published: 22 May 2021 Abstract STUDY QUESTION What is the clinical validity and utility of preconception Expanded Carrier Screening (ECS) application on the management of prospective parents? SUMMARY ANSWER The high detection rate of at-risk couples (ARCs) and the high proportion opting for IVF/preimplantation genetic testing (PGT) treatment demonstrate the clinical utility of ECS in the preconception space
Is a randomized controlled design sufficient for a trial to be valuable? Filippo Maria Ubaldi, Danilo Cimadomo, Alberto Vaiarelli, Laura Rienzi Human Reproduction, deab 114, https://doi.org/10.1093/humrep/deab114 Published: 16 May 2021 LETTER TO THE EDITOR
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives Roberta Maggiulli, Alberto Vaiarelli, Danilo Cimadomo, Adriano Giancani , Luisa Tacconi, Gemma Fabozzi, Filippo Maria Ubaldi, Laura Rienzi Jove April 28, 2021, doi:10.3791/61963 (2021) jove.com/t/61963 Abstract Preserving female fertility is crucial in a multifunctional healthcare system that takes care of patients’ future quality of life. Oocyte cryopreservation is recognized by several international scientific societies as the gold standard for fertility preservation in postpubertal women, for both medical and non-medical indications. The main medical indications are oncologic diseases, gynecologic diseases such as severe endometriosis, systemic diseases compromising the ovarian reserve, and genetic