Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines Sandro C. Esteves, Alessandro Conforti, Sesh, Sunkara, Luigi Carbone, Silvia Picarelli, Alberto Vaiarelli, Danilo Cimadomo, Laura Rienzi, Filippo Maria Ubaldi, Fulvio Zullo, Claus Yding Andersen, Raoul Orvieto, Peter Humaidan, and Carlo Alviggi Frontiers in Endocrinology – published: 19 March 2021 doi: 10.3389/fendo.2021.587051 Abstract The POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) criteria were developed to help clinicians identify and classify low-prognosis patients undergoing assisted reproductive technology (ART) and provide guidance for possible therapeutic strategies to overcome infertility. Since its introduction, the number of published studies using the POSEIDON criteria has increased steadily. However,
La qualità scientifica del nostro gruppo ha portato alla pubblicazione di oltre 200 articoli su riviste scientifiche internazionali.
“Si cura meglio dove si fa ricerca”.
Oocyte competence is independent of the ovulation trigger adopted: a large observational study in a setting that entails vitrified-warmed single euploid blastocyst transfer
Oocyte competence is independent of the ovulation trigger adopted: a large observational study in a setting that entails vitrified-warmed single euploid blastocyst transfer Danilo Cimadomo, Alberto Vaiarelli, Cecilia Petriglia, Gemma Fabozzi, Susanna Ferrero, Mauro Schimberni, Cindy Argento, Silvia Colamaria, Maddalena Giuliani, Nicolò Ubaldi, Laura Rienzi & Filippo Maria Ubaldi Journal of Assisted Reproduction and Genetics, Published: 04 March 2021 Abstract Purpose: To assess whether the GnRH-agonist or urinary-hCG ovulation triggers affect oocyte competence in a setting entailing vitrified-warmed euploid blastocyst transfer. Methods: Observational study (April 2013–July 2018) including 2104 patients (1015 and 1089 in the GnRH-a and u-hCG group, respectively) collecting ≥1 cumulus-oocyte-complex (COC) and undergoing ICSI with ejaculated sperm, blastocyst culture, trophectoderm
Is it in our patients’ blood? On a quest for predictors of blastocysts’ aneuploidy rate Danilo Cimadomo, Laura Rienzi, Filippo Maria Ubaldi Fertility and Sterility Published:February 26, 2021 DOI:https://doi.org/10.1016/j.fertnstert.2021.02.013 Abstract Reflections on “Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization” by Hanson et al.
Reply: ‘Second stimulation in the same ovarian cycle’, probably a terminology more appropriate than ‘luteal phase stimulation’ in the DuoStim protocol
Reply: ‘Second stimulation in the same ovarian cycle’, probably a terminology more appropriate than ‘luteal phase stimulation’ in the DuoStim protocol Alberto Vaiarelli, Danilo Cimadomo, Laura Rienzi, Filippo Maria Ubaldi Human Reproduction, deab018, https://doi.org/10.1093/humrep/deab018 Published: 22 February 2021
Leave the past behind: women's reproductive history shows no association with blastocysts' euploidy and limited association with live birth rates after euploid embryo transfers
Leave the past behind: women’s reproductive history shows no association with blastocysts’ euploidy and limited association with live birth rates after euploid embryo transfers Danilo Cimadomo, Antonio Capalbo, Lisa Dovere, Luisa Tacconi, Daria Soscia, Adriano Giancani, Emiliano Scepi, Roberta Maggiulli, Alberto Vaiarelli, Laura Rienzi, Filippo Maria Ubaldi Human Reproduction, pp. 1-12, 2021 Feb 20; deab 014. doi: 10.1093/humrep/deab014 Abstract STUDY QUESTION: Is there an association between patients’ reproductive history and the mean euploidy rates per biopsied blastocysts (m-ER) or the live birth rates (LBRs) per first single vitrified-warmed euploid blastocyst transfers? SUMMARY ANSWER: Patients’ reproductive history (as annotated during counselling) showed no association with the m-ER, but a lower LBR
The Impact of Unbalanced Maternal Nutritional Intakes on Oocyte Mitochondrial Activity: Implications for Reproductive Function
The Impact of Unbalanced Maternal Nutritional Intakes on Oocyte Mitochondrial Activity: Implications for Reproductive Function Gemma Fabozzi, Benedetta Iussig, Danilo Cimadomo, Alberto Vaiarelli, Roberta Maggiulli, Nicolò Ubaldi, Filippo Maria Ubaldi and Laura Rienzi Antioxidants 2021, 10, 91. https://doi.org/ 10.3390/antiox10010091 – Received: 30 November 2020 Accepted: 7 January 2021 Published: 11 January 2021 Abstract Accumulating evidence on the effect of nutrition on reproduction is emerging from both animal and human studies. A healthy dietary pattern and nutrient supplementation, especially during the peri-conceptional period, might be helpful to achieve a live birth, although the mechanisms implicated are not fully understood. The
Practical Clinical and Diagnostic Pathway for the Investigation of the Infertile Couple Andrea Garolla, Damiano Pizzol, Andrea Roberto Carosso, Andrea Borini, Filippo Maria Ubaldi, Aldo Eugenio Calogero, Alberto Ferlin, Antonio Lanzone, Francesco Tomei, Bruno Eng, Laura Rienzi, Lucia De Santis, Giovanni Coticchio, Lee Smith, Rossella Cannarella, Attilio Anastasi, Massimo Menegazzo, Liborio Stuppia, Christian Corsini, Carlo Foresta Frontiers in Endocrinology, 19 January 2021 | https://doi.org/10.3389/fendo.2020.591837
Definition, diagnostic and therapeutic options in recurrent implantation failure: an international survey of clinicians and embryologists
Definition, diagnostic and therapeutic options in recurrent implantation failure: an international survey of clinicians and embryologists D. Cimadomo, L. Craciunas, N. Vermeulen, K. Vomstein, B. Toth Human Reproduction, deaa317, https://doi.org/10.1093/humrep/deaa317 Published: 12 December 2020 Abstract STUDY QUESTION: What is the global variability in recurrent implantation failure (RIF) definition, investigation and therapy, currently offered to patients undergoing IVF? SUMAMRY ANSWER: Definitions, diagnostic investigations and treatments offered to RIF patients differ widely amongst assisted repro- duction healthcare professionals and clinical guidelines on RIF are urgently needed. WHAT IS KNOWN ALREADY: RIF affects around 10% of patients undergoing IVF worldwide. There is
Blastulation rates of sibling oocytes in two IVF culture media: an evidence-based workflow to implement newly commercialized products
Blastulation rates of sibling oocytes in two IVF culture media: an evidence-based workflow to implement newly commercialized products Gemma Fabozzi, Laura Albricci, Danilo Cimadomo, Maria Giulia Amendola, Federica Sanges, Roberta Maggiulli, Filippo Maria Ubaldi, Laura Rienzi RBMO Reproductive Biomedicine Online Published:November 04, 2020DOI:https://doi.org/10.1016/j.rbmo.2020.10.017 ABSTRACT Research question: An evidence-based novel commercially available continuous IVF culture medium in compliance with an efficient quality-management system is proposed. Design: Non-interventional study on sibling oocytes. Intracytoplasmic sperm injection cycles among women aged 42 years or younger that used ejaculated spermatozoa and retrieved four to eight oocytes were included. Sibling oocytes were randomized for culture
When embryology meets genetics: the definition of developmentally incompetent preimplantation embryos (DIPE)—the consensus of two Italian scientific societies
When embryology meets genetics: the definition of developmentally incompetent preimplantation embryos (DIPE)—the consensus of two Italian scientific societies Danilo Cimadomo, Antonio Capalbo, Catello Scarica, Laura Sosa, Fernandez, Laura Rienzi, Rosanna Ciriminna, Maria Giulia Minasi, Antonio Novelli, Lucia De Santis, Daniela Zuccarello Journal of Assisted Reproduction and Genetics https://doi.org/10.1007/s10815-020-02015-x – Received: 15 July 2020 / Accepted: 12 November 2020 Abstract A clear definition of developmentally incompetent preimplantation embryo (DIPE) in literature is still missing, while several scientific societies are discussing this challenging topic. From both a clinical and scientific perspective, the identification of embryos unfit for reproductive purpose is crucial. This