Dr. Danilo Cimadomo




Danilo Cimadomo Received his Bachelor of Science degree magna cum laude in Biotechnology at University of Pavia (Italy)


Master of Science magna cum laude and a special mention in Molecular Biology and Genetics at the same University


He attended to a specialization course in Novel technologies in molecular medicine at the University of Padova (Italy).


He obtained his PhD at the University of Rome with a Thesis entitled “MicroRNAs in human spent blastocyst culture media: mediators of an embryo-endometrium dialogue. Novel potential non-invasive biomarkers of reproductive competence in IVF”.



between 2009 and 2012

He has followed a three-year internship in the laboratory headed by Prof. Carlo Alberto Redi, Prof. Silvia Garagna and Prof. Maurizio Zuccotti at the University of Pavia (Italy)

Summer 2011

He has also followed a three-month internship in the lab headed by Prof. Miguel Constancia at the University of Cambridge (UK)

Since 2012 to today

He has been working as science and research manager of the GENERA centers, centers for reproductive medicine (Italy) (Clinical director: Dr Filippo Maria Ubaldi; Laboratory director: Dr Laura Rienzi).

Since October 2017 to today

He is the scientific coordinator of the GENERA centers for reproductive medicine (Italy).



His research is focused on preimplantation genetic testing and on the development and validation of novel molecular methods to improve embryo selection and take-home baby rates in IVF.


He participated in the project entitled “Secreted miRNAs can be profiled with high accuracy and reproducibility from blastocyst spent culture media: a new promise for non-invasive biomarkers of embryo quality” awarded with the Grant for Fertility Innovation


He was awarded with the second prize for the best oral presentation at the “National Meeting of reproductive medicine” in Riccione for a study entitled “Influence of morphological quality and developmental rate to blastocyst on the developmental competence of euploid embryos: a prospective non-selection study”


He was awarded with the third prize for the best oral presentation at the “National Meeting of reproductive medicine” in Riccione for a study entitled “Technical and clinical outcomes associated with blastocyst stage biopsy and aneuploidy screening are consistent and reproducible across different operators: a multicentre study of 2586 biopsies”.


He participated in the project entitled “Clinical translation of a new procedure for embryo evaluation based on miRNAs profiling from spent blastocyst culture media: prospective multicenter study” awarded with the Grant for Fertility Innovation


He was awarded with the first prize for the oral presentation at the “National Meeting of reproductive medicine” in Riccione for a study entitled “Characterization of the human blastocyst miRNome: Inner Cell Mass, trophectoderm and related Spent Blastocyst Media”.


He presented two studies at the ESHRE annual meetings in 2015 in Lisbon and in 2016 in Helsinki, based on the characterization of the whole miRNome of the human blastocyst, as well as two posters at the ESHRE annual meetings in 2017 in Geneva (analysis of qPCR plots compatible with segmental aneuploidies and/or chromosomal mosaicism) and in 2018 in Barcelona (comprehensive analysis of blastocyst re-biopsies after qPCR-based based aneuploidy testing).


He obtained a grant from the University of Rome “Sapienza” for the project “Secreted miRNAs in the human blastocyst spent culture media: messengers of a dialogue between the embryo and the endometrium. A novel possibility to identify non-invasive biomarkers of reproductive competence”.


He is reviewer for Human Reproduction, Human Reproduction Open, Journal of Assisted Reproduction and Genetics, Reproductive Biomedicine online and other journals in the field of reproductive medicine. In the period 2017-2018, he was awarded among the top 10% of the journal’s reviewers as judged by the quality and timeliness of his reviews by Human Reproduction and Human Reproduction Open.

Since 2020 to today

He is associate editor of the journal Human Reproduction Update.

He is registered in ESHRE, in SIERR (Italian society of embryology, research and reproduction) and in SIFES (Italian society of fertility and sterility).

Between 2018 and 2020

He has been part of the scientific committee of SIERR. Since 2020, he is member of the executive committee of SIERR


He was selected to participate in an ESHRE working group upon embryo biopsy during IVF aimed at updating the ESHRE guidelines related with such clinical procedure.


He was selected as basic science officer of the special interest group (SIG) in implantation and early pregnancy of ESHRE.



He published more than 70 papers in international journals, as well as book chapters and several abstracts at national and international meetings. He participated to more than 70 congresses in the field of reproductive medicine as speaker or chairman.


74. Alessandro Conforti, Sandro C. Esteves, Peter Humaidan, Salvatore Longobardi, Thomas D’Hooghe, Raoul Orvieto, Alberto Vaiarelli, Danilo Cimadomo, Laura Rienzi, Filippo Maria Ubaldi, Fulvio Zullo and Carlo Alviggi, “Recombinant human luteinizing hormone co-treatment in ovarian stimulation for assisted reproductive technology in women of advanced reproductive age: a systematic review and meta-analysis of randomized controlled trials”, Reproductive Biology and Endocrinology https://doi.org/10.1186/s12958-021-00759-4 – Published: 

73. A.Capalbo, M. Fabiani, S. Caroselli, M. Poli, L. Girardi, C. Patassini, F. Favero, D. Cimadomo, A. Vaiarelli, C. Simon, L. F. Rienzi, F. M. Ubaldi “Clinical validity and utility of preconception expanded carrier screening for the management of reproductive genetic risk in IVF and general population”, Human Reproduction, deab 087, https://doi.org/10.1093/humrep/deab087 Published: 22 May 2021

72. Filippo Maria Ubaldi, Danilo Cimadomo, Alberto Vaiarelli, Laura Rienzi, “Is a randomized controlled design sufficient for a trial to be valuable?” Letter to the editor, Human Reproduction, deab 114, https://doi.org/10.1093/humrep/deab114 Published: 16 May 2021

71. Roberta Maggiulli, Alberto Vaiarelli, Danilo Cimadomo, Adriano Giancani , Luisa Tacconi, Gemma Fabozzi, Filippo Maria Ubaldi, Laura Rienzi, “Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives”,  Jove April 28, 2021,  doi:10.3791/61963 (2021)  jove.com/t/61963

70. Sandro C. Esteves, Alessandro Conforti, Sesh, Sunkara, Luigi Carbone, Silvia Picarelli, Alberto Vaiarelli, Danilo Cimadomo, Laura Rienzi, Filippo Maria Ubaldi, Fulvio Zullo, Claus Yding Andersen, Raoul Orvieto, Peter Humaidan, and Carlo Alviggi, “Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines”,  Frontiers in Endocrinology – published: 19 March 2021 doi: 10.3389/fendo.2021.587051

69. Danilo Cimadomo, Alberto Vaiarelli, Cecilia Petriglia, Gemma Fabozzi, Susanna Ferrero, Mauro Schimberni, Cindy Argento, Silvia Colamaria, Maddalena Giuliani, Nicolò Ubaldi, Laura Rienzi &Filippo Maria Ubaldi, “Oocyte competence is independent of the ovulation trigger adopted: a large observational study in a setting that entails vitrified-warmed single euploid blastocyst transfer”,  Journal of Assisted Reproduction and Genetics, Published: 

68. Danilo Cimadomo, Laura Rienzi, Filippo Maria Ubaldi, “Is it in our patients’ blood? On a quest for predictors of blastocysts’ aneuploidy rate”, Fertility and Sterility Published:February 26, 2021 DOI:https://doi.org/10.1016/j.fertnstert.2021.02.013

67. Alberto Vaiarelli, Danilo Cimadomo, Laura Rienzi, Filippo Maria Ubaldi, “Reply: ‘Second stimulation in the same ovarian cycle’, probably a terminology more appropriate than ‘luteal phase stimulation’ in the DuoStim protocol” , Human Reproduction, deab018, https://doi.org/10.1093/humrep/deab018 Published: 22 February 2021

66. Danilo CimadomoAntonio CapalboLisa DovereLuisa TacconiDaria SosciaAdriano GiancaniEmiliano ScepiRoberta MaggiulliAlberto VaiarelliLaura Rienzi, Filippo Maria Ubaldi, Leave the past behind: women’s reproductive history shows no association with blastocysts’ euploidy and limited association with live birth rates after euploid embryo transfers”, Human Reproduction, pp. 1-12, 2021 Feb 20; deab 014. doi: 10.1093/humrep/deab014 

65. Gemma Fabozzi, Benedetta Iussig, Danilo Cimadomo, Alberto Vaiarelli, Roberta Maggiulli, Nicolò Ubaldi, Filippo Maria Ubaldi and Laura Rienzi, “The Impact of Unbalanced Maternal Nutritional Intakes on Oocyte Mitochondrial Activity: Implications for Reproductive Function”, Antioxidants 2021, 10, 91. https://doi.org/ 10.3390/antiox10010091 – Received: 30 November 2020 Accepted: 7 January 2021 Published: 11 January 2021


64. Danilo Cimadomo, Antonio Capalbo, Catello Scarica, Laura Sosa, Fernandez, Laura Rienzi, Rosanna Ciriminna, Maria Giulia Minasi, Antonio Novelli, Lucia De Santis, Daniela Zuccarello, “When embryology meets genetics: the definition of developmentally incompetent preimplantation embryos (DIPE)—the consensus of two Italian scientific societies”, Journal of Assisted Reproduction and Genetics https://doi.org/10.1007/s10815-020-02015-x – Received: 15 July 2020 / Accepted: 12 November 2020

63. Gemma Fabozzi, Laura Albricci, Danilo Cimadomo, Maria Giulia Amendola, Federica Sanges, Roberta Maggiulli, Filippo Maria Ubaldi, Laura Rienzi, “Blastulation rates of sibling oocytes in two IVF culture media: an evidence-based workflow to implement newly commercialized products”, RBMO Reproductive Published:November 04, 2020 DOI:https://doi.org/10.1016/j.rbmo.2020.10.017

62. Alberto Vaiarelli, Roberta Venturella, Danilo Cimadomo, Alessandro Conforti, Sara Pedri, Giovanna Bitonti, Benedetta Iussig, Cinzia Gentile, Erminia Alviggi, Serena Santopaolo, Fulvio Zullo, Laura Rienzia, Filippo Maria Ubaldi, “Endometriosis shows no impact on the euploid blastocyst rate per cohort of inseminated metaphase-II oocytes: A case-control study”, European Journal of Obstetrics & Gynecology and Reproductive Biology Published: November 11, 2020 DOI:https://doi.org/10.1016/j.ejogrb.2020.11.024

61. Alessandro Conforti, Silvia Picarelli, Luigi Carbone, Antonio La Marca, Roberta Venturella, Alberto Vaiarelli, Danilo Cimadomo, Fulvio Zullo, Laura Rienzi, Filippo Maria Ubaldi, Carlo Alviggi, “Perinatal and obstetric outcomes in singleton pregnancies following fresh versus cryopreserved blastocyst transfer: a meta-analysis”, RBMO Published:October 05, 2020 DOI:https://doi.org/10.1016/j.rbmo.2020.09.029

60. Lucia De Santis, Danilo Cimadomo, Antonio Capalbo, Cinzia Di Pietro, Daniela Zuccarello, Attilio Anastasi, Emanuele Licata, Catello Scarica, Laura Sosa Fernandez, Francesca Gioia Klinger, On behalf of the Italian Society of Embryology, Reproduction and Research (SIERR), “IUI and uterine lavage of in vivo–produced blastocysts for PGT purposes: is it a technically and ethically reasonable perspective? Is it actually needed?”, Jornal of Assisted Reproduction and Genetics (2020) 37:1579–1582 https://doi.org/10.1007/s10815-020-01813-7 – Received: 7 April 2020 / Accepted: 7 May 2020 / Published online: 26 May 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020

59. Alberto Vaiarelli, Danilo Cimadomo, Erminia Alviggi, Anna Sansone, Elisabetta Trabucco, Ludovica Dusi, Laura Buffo, Nicoletta Barnocchi, Fabrizio Fiorini, Silvia Colamaria, Maddalena Giuliani, Cindy Argento, Laura Rienzi, and Filippo Maria Ubaldi, “The euploid blastocysts obtained after luteal phase stimulation show the same clinical, obstetric and perinatal outcomes as follicular phase stimulation-derived ones: a multicenter study”, Human Reproduction, Vol.00, No.0, pp. 1–11, 2020 doi:10.1093/humrep/deaa203 – Submitted on April 6, 2020; resubmitted on July 13, 2020; editorial decision on July 22, 2020 – Published: 20 September 2020

58. Roberta Maggiulli, Adriano Giancani, Gemma Fabozzi, Lisa Dovere, Luisa Tacconi, Maria Giulia Amendola, Danilo Cimadomo, Filippo Maria Ubaldi, Laura Rienzi, “Assessment and management of the risk of SARS-CoV-2 infection in an IVF laboratory”, RBMO – Published: June 27, 2020 DOI:https://doi.org/10.1016/j.rbmo.2020.06.017

57. Gemma Fabozzi, Danilo Cimadomo, Roberta Maggiulli, Alberto Vaiarelli, Filippo Maria Ubaldi, and Laura Rienzi, “Which key performance indicators are most effective in evaluating and managing an in vitro fertilization laboratory?”, Fertility and Sterility 2020 – DOI: https://doi.org/10.1016/j.fertnstert.2020.04.054

56. Danilo Cimadomo,  Laura Rienzi, Antonio Capalbo, Carmen Rubio, Federica Innocenti, Carmen María García-Pascual, Filippo Maria Ubaldi, and Alan Handyside, “The dawn of the future: 30 years from the first biopsy of a human embryo. The detailed history of an ongoing revolution”, Human Reproduction Update, pp. 1–21, 2020 – https://doi.org/10.1093/humupd/dmaa019  Submitted on November 30, 2019; resubmitted on March 25, 2020; editorial decision on March 31, 2020; Published: on May 22, 2020

55. Alberto Vaiarelli, Carlo Bulletti, Danilo Cimadomo, Andrea Borini, Carlo Alviggi, Silvia Ajossa, Paola Anserini, Gianluca Gennarelli, Maurizio Guido, Paolo E Levi-Setti, Antonio Palagiano, Roberto Palermo, Valeria Savasi, Antonio Pellicer, Laura Rienzi, Filippo M. Ubaldi, “COVID-19 and ART, the view of the Italian Society of Fertility and Sterility and Reproductive Medicine”, RBMO Published: April 08, 2020DOI:https://doi.org/10.1016/j.rbmo.2020.04.003

54. Alberto Vaiarelli, Danilo Cimadomo, Cecilia Petriglia, Alessandro Conforti, Carlo Alviggi, Nicolò Ubaldi, Sergio Ledda, Susanna Ferrero, Laura Rienzi and Filippo Maria Ubaldi, “DuoStim – a reproducible strategy to obtain more oocytes and competent embryos in a short time- frame aimed at fertility preservation and IVF purposes. A systematic review”, UPSALA JOURNAL OF MEDICAL SCIENCES Received 08 Nov 2019, Accepted 21 Feb 2020, Published online: 25 Apr 2020 https://doi.org/10.1080/03009734.2020.1734694

53. Lucia De Santis, Attilio Anastasi, Danilo Cimadomo, Francesca Gioia Klinger, Emanuele Licata, Valerio Pisaturo, Laura Sosa Fernandez, and Catello Scarica, “COVID-19: the perspective of Italian embryologists managing the IVF laboratory in pandemic emergency”, Human Reproduction, pp. 1–2, 2020 doi:10.1093/humrep/deaa074

52. Alberto Vaiarelli, Carlo Bulletti, Danilo Cimadomo, Andrea Borini, Cindy Argento, Carlo Alviggi, Silvia Ajossa, Paola Anserini, Gianluca Gennarelli, Maurizio Guido, Paolo Emanuele Levi-Setti, Antonio Palagiano, Roberto Palermo, Valeria Savasi, Antonio PellicerLuca Gianaroli, Laura Rienzi, Filippo Maria Ubaldi, “Are there specific patients candidate for oocyte collection during COVID-19 pandemic?”, Fertility and Sterility – April 1°, 2020

51. Laura Rienzi, Danilo Cimadomo, Roberta Maggiulli, Alberto Vaiarelli, Ludovica Dusi, Laura Buffo,
Maria Giulia Amendola, Silvia Colamaria, Maddalena Giuliani, Giulietta Bruno, Marta Stoppa, and Filippo Maria Ubaldi, “Definition of a clinical strategy to enhance the e cacy e ciency and safety of egg donation cycles with imported vitrified oocytes”; Human Reproduction, pp. 1–11, 2020 doi:10.1093/humrep/deaa009; Submitted on October 5, 2019; resubmitted on January 13, 2020; editorial decision on January 17, 2020

50. Laura Girardi, Munevver Serdarogullari, Cristina Patassini, Maurizio Poli, Marco Fabiani, Silvia Caroselli, Onder Coban, Necati Findikli, Fazilet Kubra Boynukalin, Mustafa Bahceci, Rupali Chopra, Rita Canipari, Danilo Cimadomo, Laura Rienzi, Filippo Ubaldi, Eva Hoffmann, Carmen Rubio, Carlos Simon, and Antonio Capalbo, “Incidence, Origin, and Predictive Model for the Detection and Clinical Management of Segmental Aneuploidies in Human Embryos”, The American Journal of Human Genetics 106, 1–10, April 2, 2020

49. Esteves SC, Yarali H, Ubaldi FM, Carvalho JF, Bento FC, Vaiarelli A, Cimadomo D, Özbek İY, Polat M, Bozdag G, Rienzi L, Alviggi C. “Validation of ART Calculator for Predicting the Number of Metaphase II Oocytes Required for Obtaining at Least One Euploid Blastocyst for Transfer in Couples Undergoing in vitro Fertilization/Intracytoplasmic Sperm Injection. Front Endocrinol (Lausanne)”, 2020 Jan 24;10:917. doi: 10.3389/fendo.2019.00917. eCollection 2019. PubMed PMID:32038484; PubMed Central PMCID: PMC6992582.

48. Maggiulli R, Cimadomo D, Fabozzi G, Papini L, Dovere L, Ubaldi FM, Rienzi L. “The effect of ICSI-related procedural timings and operators on the outcome”. Hum Reprod. 2020 Jan 1;35(1):32-43. doi: 10.1093/humrep/dez234. PubMed PMID:31916573.

47. Vaiarelli A, Cimadomo D, Conforti A, Schimberni M, Giuliani M, D’Alessandro P, Colamaria S, Alviggi C, Rienzi L, Ubaldi FM. Luteal phase after conventional stimulation in the same ovarian cycle might improve the management of poor responder patients fulfilling the Bologna criteria: a case series. Fertil Steril. 2020 Jan;113(1):121-130. doi: 10.1016/j.fertnstert.2019.09.012. Epub 2019 Dec 16. PubMed PMID: 31837743.


46. Rienzi L, Cimadomo D, Delgado A, Minasi MG, Fabozzi G, Gallego RD, Stoppa M, Bellver J, Giancani A, Esbert M, Capalbo A, Remohì J, Greco E, Ubaldi FM, Meseguer M. Time of morulation and trophectoderm quality are predictors of a live birth after euploid blastocyst transfer: a multicenter study. Fertil Steril. 2019 Dec;112(6):1080-1093.e1. doi: 10.1016/j.fertnstert.2019.07.1322. PubMed PMID:31843084.

45. Esteves SC, Alviggi C, Humaidan P, Fischer R, Andersen CY, Conforti A, Bühler K, Sunkara SK, Polyzos NP, Galliano D, Grynberg M, Yarali H, Özbek IY, Roque M, Vuong LN, Banker M, Rienzi L, Vaiarelli A, Cimadomo D, Ubaldi FM. The POSEIDON Criteria and Its Measure of Success Through the Eyes of Clinicians and Embryologists. Front Endocrinol (Lausanne). 2019 Nov 20;10:814. doi: 10.3389/fendo.2019.00814. eCollection 2019. PubMed PMID: 31824427; PubMed Central PMCID: PMC6880663.

44. Cimadomo D, Carmelo R, Parrotta EI, Scalise S, Santamaria G, Alviggi E, De Angelis MT, Sarro G, Vaiarelli A, Venturella R, Rienzi L, Zullo F, Ubaldi FM, Cuda G. Similar miRNomic signatures characterize the follicular fluids collected after follicular and luteal phase stimulations in the same ovarian cycle. J Assist Reprod Genet. 2020 Jan;37(1):149-158. doi: 10.1007/s10815-019-01607-6. Epub 2019 Nov 7. PubMed PMID: 31701304.

43. Gruhn JR, Zielinska AP, Shukla V, Blanshard R, Capalbo A, Cimadomo D, Nikiforov D, Chan AC, Newnham LJ, Vogel I, Scarica C, Krapchev M, Taylor D, Kristensen SG, Cheng J, Ernst E, Bjørn AB, Colmorn LB, Blayney M, Elder K, Liss J, Hartshorne G, Grøndahl ML, Rienzi L, Ubaldi F, McCoy R, Lukaszuk K, Andersen CY, Schuh M, Hoffmann ER. Chromosome errors in human eggs shape natural fertility over reproductive life span. Science. 2019 Sep 27;365(6460):1466-1469. doi: 10.1126/science.aav7321. PubMed PMID: 31604276.

42. Cimadomo D, Rienzi L, Giancani A, Alviggi E, Dusi L, Canipari R, Noli L, Ilic D, Khalaf Y, Ubaldi FM, Capalbo A. Definition and validation of a custom protocol to detect miRNAs in the spent media after blastocyst culture: searching for biomarkers of implantation. Hum Reprod. 2019 Sep 29;34(9):1746-1761. doi: 10.1093/humrep/dez119. PubMed PMID: 31419301.

41. Maggiulli R, Giancani A, Cimadomo D, Ubaldi FM, Rienzi L. Human Blastocyst Biopsy and Vitrification. J Vis Exp. 2019 Jul 26;(149). doi: 10.3791/59625. PubMed PMID: 31403619.

40. Conforti A, Esteves SC, Cimadomo D, Vaiarelli A, Di Rella F, Ubaldi FM, Zullo F, De Placido G, Alviggi C. Management of Women With an Unexpected Low Ovarian Response to Gonadotropin. Front Endocrinol (Lausanne). 2019 Jun 27;10:387. doi: 10.3389/fendo.2019.00387. eCollection 2019. Review. PubMed PMID: 31316461; PubMed Central PMCID: PMC6610322.

39. Conforti A, Vaiarelli A, Cimadomo D, Bagnulo F, Peluso S, Carbone L, Di Rella F, De Placido G, Ubaldi FM, Huhtaniemi I, Alviggi C. Pharmacogenetics of FSH Action in the Female. Front Endocrinol (Lausanne). 2019 Jun 26;10:398. doi: 10.3389/fendo.2019.00398. eCollection 2019. Review. PubMed PMID: 31293516; PubMed Central PMCID: PMC6606727.

38. Cimadomo D, Soscia D, Vaiarelli A, Maggiulli R, Capalbo A, Ubaldi FM, Rienzi L. Looking past the appearance: a comprehensive description of the clinical contribution of poor-quality blastocysts to increase live birth rates during cycles with aneuploidy testing. Hum Reprod. 2019 Jul 8;34(7):1206-1214. doi: 10.1093/humrep/dez078. PubMed PMID: 31247100.

37. Mazzilli R, Stigliano A, Delfino M, Olana S, Zamponi V, Iorio C, Defeudis G, Cimadomo D, Toscano V, Mazzilli F. The High Prevalence of Testicular Adrenal Rest Tumors in Adult Men With Congenital Adrenal Hyperplasia Is Correlated With ACTH Levels. Front Endocrinol (Lausanne). 2019 Jun 4;10:335. doi: 10.3389/fendo.2019.00335. eCollection 2019. PubMed PMID: 31214118; PubMed Central PMCID: PMC6558150.

36. Rubio C, Rienzi L, Navarro-Sánchez L, Cimadomo D, García-Pascual CM, Albricci L, Soscia D, Valbuena D, Capalbo A, Ubaldi F, Simón C. Embryonic cell-free DNA versus trophectoderm biopsy for aneuploidy testing: concordance rate and clinical implications. Fertil Steril. 2019 Sep;112(3):510-519. doi: 10.1016/j.fertnstert.2019.04.038. Epub 2019 Jun 11. PubMed PMID: 31200971.

35. Faustini F, Forte M, Capalbo A, Cimadomo D, Ubaldi FM, Rienzi L. The main will of the patients of a private Italian IVF clinic for their aneuploid/affected blastocysts would be donation to research: a currently forbidden choice. J Assist Reprod Genet. 2019 Aug;36(8):1555-1560. doi: 10.1007/s10815-019-01465-2. Epub 2019 May 27. PubMed PMID: 31134411; PubMed Central PMCID: PMC6708053.

34. Venturella R, Vaiarelli A, Cimadomo D, Pedri S, Lico D, Mazzilli R, Mocciaro R, Rienzi L, Di Carlo C, Ubaldi FM, Zullo F. State of the art and emerging drug therapies for female infertility. Gynecol Endocrinol. 2019 Apr 29:1-7. doi: 10.1080/09513590.2019.1603289. [Epub ahead of print] PubMed PMID: 31032671.

33. Rienzi LF, Iussig B, Dovere L, Fabozzi G, Cimadomo D, Ubaldi FM. Perspectives in Gamete and Embryo Cryopreservation. Semin Reprod Med. 2018 Sep;36(5):253-264. doi: 10.1055/s-0038-1677463. Epub 2019 Apr 4. Review. PubMed PMID: 30947341.

32. Vaiarelli A, Cimadomo D, Argento C, Ubaldi N, Trabucco E, Drakopoulos P, Venturella R, Conforti A, Alviggi C, Rienzi L, Ubaldi FM. Double stimulation in the same ovarian cycle (DuoStim) is an intriguing strategy to improve oocyte yield and the number of competent embryos in a short timeframe. Minerva Ginecol. 2019 Oct;71(5):372-376. doi: 10.23736/S0026-4784.19.04390-9. Epub 2019 Mar 4. PubMed PMID: 30848112.

31. Ubaldi FM, Cimadomo D, Vaiarelli A, Fabozzi G, Venturella R, Maggiulli R, Mazzilli R, Ferrero S, Palagiano A, Rienzi L. Advanced Maternal Age in IVF: Still a Challenge? The Present and the Future of Its Treatment. Front Endocrinol (Lausanne). 2019 Feb 20;10:94. doi: 10.3389/fendo.2019.00094. eCollection 2019. Review. PubMed PMID: 30842755; PubMed Central PMCID: PMC6391863.

30. Iussig B, Maggiulli R, Fabozzi G, Bertelle S, Vaiarelli A, Cimadomo D, Ubaldi FM, Rienzi L. A brief history of oocyte cryopreservation: Arguments and facts. Acta Obstet Gynecol Scand. 2019 May;98(5):550-558. doi: 10.1111/aogs.13569. Epub 2019 Mar 25. Review. PubMed PMID: 30739329.

29. Scarica C, Cimadomo D, Dovere L, Giancani A, Stoppa M, Capalbo A, Ubaldi FM, Rienzi L, Canipari R. An integrated investigation of oocyte developmental competence: expression of key genes in human cumulus cells, morphokinetics of early divisions, blastulation, and euploidy. J Assist Reprod Genet. 2019 May;36(5):875-887. doi: 10.1007/s10815-019-01410-3. Epub 2019 Feb 1. PubMed PMID: 30710230; PubMed Central PMCID: PMC6541693.

28. Capalbo A, Romanelli V, Patassini C, Poli M, Girardi L, Giancani A, Stoppa M, Cimadomo D, Ubaldi FM, Rienzi L. Diagnostic efficacy of blastocoel fluid and spent media as sources of DNA for preimplantation genetic testing in standard clinical conditions. Fertil Steril. 2018 Oct;110(5):870-879.e5. doi: 10.1016/j.fertnstert.2018.05.031. Erratum in: Fertil Steril. 2019 Jan;111(1):194. PubMed PMID: 30316433.


27. Vaiarelli A, Cimadomo D, Patrizio P, Venturella R, Orlando G, Soscia D, Giancani A, Capalbo A, Rienzi L, Ubaldi FM. Biochemical pregnancy loss after frozen embryo transfer seems independent of embryo developmental stage and chromosomal status. Reprod Biomed Online. 2018 Sep;37(3):349-357. doi: 10.1016/j.rbmo.2018.05.019. Epub 2018 Jun 30. PubMed PMID: 30314887.

26. Cimadomo D, Capalbo A, Levi-Setti PE, Soscia D, Orlando G, Albani E, Parini V, Stoppa M, Dovere L, Tacconi L, Ievoli E, Maggiulli R, Ubaldi FM, Rienzi L. Associations of blastocyst features, trophectoderm biopsy and other laboratory practice with post-warming behavior and implantation. Hum Reprod. 2018 Nov 1;33(11):1992-2001. doi: 10.1093/humrep/dey291. PubMed PMID: 30265329.

25. Cimadomo D, Rienzi L, Romanelli V, Alviggi E, Levi-Setti PE, Albani E, Dusi L, Papini L, Livi C, Benini F, Smeraldi A, Patassini C, Ubaldi FM, Capalbo A. Inconclusive chromosomal assessment after blastocyst biopsy: prevalence, causative factors and outcomes after re-biopsy and re-vitrification. A multicenter experience. Hum Reprod. 2018 Oct 1;33(10):1839-1846. doi: 10.1093/humrep/dey282. PubMed PMID: 30239718.

24. Cimadomo D, Fabozzi G, Vaiarelli A, Ubaldi N, Ubaldi FM, Rienzi L. Impact of Maternal Age on Oocyte and Embry Competence. Front Endocrinol (Lausanne). 2018 Jun 29;9:327. doi: 10.3389/fendo.2018.00327. eCollection 2018. Review. PubMed PMID: 30008696; PubMed Central PMCID: PMC6033961.

23. Vaiarelli A, Cimadomo D, Trabucco E, Vallefuoco R, Buffo L, Dusi L, Fiorini F, Barnocchi N, Bulletti FM, Rienzi L, Ubaldi FM. Double Stimulation in the Same Ovarian Cycle (DuoStim) to Maximize the Number of Oocytes Retrieved From Poor Prognosis Patients: A Multicenter Experience and SWOT Analysis. Front Endocrinol (Lausanne). 2018 Jun 14;9:317. doi: 10.3389/fendo.2018.00317. eCollection 2018. PubMed PMID: 29963011; PubMed Central PMCID: PMC6010525.

22. Cimadomo D, Vaiarelli A, Colamaria S, Trabucco E, Alviggi C, Venturella R, Alviggi E, Carmelo R, Rienzi L, Ubaldi FM. Luteal phase anovulatory follicles result in the production of competent oocytes: intra-patient paired case-control study comparing follicular versus luteal phase stimulations in the same ovarian cycle. Hum Reprod. 2018 Aug 1;33(8):1442-1448. doi: 10.1093/humrep/dey217. PubMed PMID: 29912374; PubMed Central PMCID: PMC6070116.

21. Mazzilli R, Cimadomo D, Rienzi L, Capalbo A, Levi Setti PE, Livi C, Vizziello D, Foresta C, Ferlin A, Ubaldi FM. Prevalence of XXY karyotypes in human blastocysts: multicentre data from 7549 trophectoderm biopsies obtained during preimplantation genetic testing cycles in IVF. Hum Reprod. 2018 Jul 1;33(7):1355-1363. doi: 10.1093/humrep/dey110. PubMed PMID: 29788175.

20. Cimadomo D, Scarica C, Maggiulli R, Orlando G, Soscia D, Albricci L, Romano S, Sanges F, Ubaldi FM, Rienzi L. Continuous embryo culture elicits higher blastulation but similar cumulative delivery rates than sequential: a large prospective study. J Assist Reprod Genet. 2018 Jul;35(7):1329-1338. doi: 10.1007/s10815-018-1195-4. Epub 2018 May 3. PubMed PMID: 29725911; PubMed Central PMCID: PMC6063814.

19. Vaiarelli A, Cimadomo D, Ubaldi N, Rienzi L, Ubaldi FM. What is new in the management of poor ovarian response in IVF? Curr Opin Obstet Gynecol. 2018 Jun;30(3):155-162. doi: 10.1097/GCO.0000000000000452. Review. PubMed PMID: 29664789.


18. Mazzilli R, Cimadomo D, Vaiarelli A, Capalbo A, Dovere L, Alviggi E, Dusi L, Foresta C, Lombardo F, Lenzi A, Tournaye H, Alviggi C, Rienzi L, Ubaldi FM. Effect of the male factor on the clinical outcome of intracytoplasmic sperm injection combined with preimplantation aneuploidy testing: observational longitudinal cohort study of 1,219 consecutive cycles. Fertil Steril. 2017 Dec;108(6):961-972.e3. doi: 10.1016/j.fertnstert.2017.08.033. Epub 2017 Oct 3. PubMed PMID: 28985908.

17. Capalbo A, Hoffmann ER, Cimadomo D, Ubaldi FM, Rienzi L. Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging. Hum Reprod Update. 2017 Nov 1;23(6):706-722. doi: 10.1093/humupd/dmx026. Review. PubMed PMID: 28961822.

16. Capalbo A, Treff N, Cimadomo D, Tao X, Ferrero S, Vaiarelli A, Colamaria S, Maggiulli R, Orlando G, Scarica C, Scott R, Ubaldi FM, Rienzi L. Abnormally fertilized oocytes can result in healthy live births: improved genetic technologies for preimplantation genetic testing can be used to rescue viable embryos in in vitro fertilization cycles. Fertil Steril. 2017 Dec;108(6):1007-1015.e3. doi: 10.1016/j.fertnstert.2017.08.004. Epub 2017 Sep 15. PubMed PMID: 28923286.

15. Ubaldi FM, Cimadomo D, Capalbo A, Vaiarelli A, Buffo L, Trabucco E, Ferrero S, Albani E, Rienzi L, Levi Setti PE. Preimplantation genetic diagnosis for aneuploidy testing in women older than 44 years: a multicenter experience. Fertil Steril. 2017 May;107(5):1173-1180. doi: 10.1016/j.fertnstert.2017.03.007. Epub 2017 Apr 19. PubMed PMID: 28433373.


14. Noli L, Capalbo A, Dajani Y, Cimadomo D, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D. Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c. Stem Cells Dev. 2016 Dec 15;25(24):1853-1862. Epub 2016 Oct 17. PubMed PMID: 27612589; PubMed Central PMCID: PMC5165679.

13. Vaiarelli A, Cimadomo D, Capalbo A, Orlando G, Sapienza F, Colamaria S, Palagiano A, Bulletti C, Rienzi L, Ubaldi FM. Pre-implantation genetic testing in ART: who will benefit and what is the evidence? J Assist Reprod Genet. 2016 Oct;33(10):1273-1278. Epub 2016 Aug 5. Review. PubMed PMID: 27491771; PubMed Central PMCID: PMC5065560.

12. Capalbo A, Romanelli V, Cimadomo D, Girardi L, Stoppa M, Dovere L, Dell’Edera D, Ubaldi FM, Rienzi L. Implementing PGD/PGD-A in IVF clinics: considerations for the best laboratory approach and management. J Assist Reprod Genet. 2016 Oct;33(10):1279-1286. Epub 2016 Jul 16. Review. PubMed PMID: 27423665; PubMed Central PMCID: PMC5065548.

11. Cimadomo D, Ubaldi FM, Capalbo A, Maggiulli R, Scarica C, Romano S, Poggiana C, Zuccarello D, Giancani A, Vaiarelli A, Rienzi L. Failure mode and effects analysis of witnessing protocols for ensuring traceability during PGD/PGS cycles. Reprod Biomed Online. 2016 Sep;33(3):360-9. doi: 10.1016/j.rbmo.2016.06.002. Epub 2016 Jun 23. PubMed PMID: 27372783.

10. Ottolini CS, Capalbo A, Newnham L, Cimadomo D, Natesan SA, Hoffmann ER, Ubaldi FM, Rienzi L, Handyside AH. Generation of meiomaps of genome-wide recombination and chromosome segregation in human oocytes. Nat Protoc. 2016 Jul;11(7):1229-43. doi: 10.1038/nprot.2016.075. Epub 2016 Jun 16. PubMed PMID: 27310263.

9. Ubaldi FM, Capalbo A, Vaiarelli A, Cimadomo D, Colamaria S, Alviggi C, Trabucco E, Venturella R, Vajta G, Rienzi L. Follicular versus luteal phase ovarian stimulation during the same menstrual cycle (DuoStim) in a reduced ovarian reserve population results in a similar euploid blastocyst formation rate: new insight in ovarian reserve exploitation. Fertil Steril. 2016 Jun;105(6):1488-1495.e1. doi: 10.1016/j.fertnstert.2016.03.002. Epub 2016 Mar 25. PubMed PMID: 27020168.

8. Cimadomo D, Capalbo A, Ubaldi FM, Scarica C, Palagiano A, Canipari R, Rienzi L. The Impact of Biopsy on Human Embryo Developmental Potential during Preimplantation Genetic Diagnosis. Biomed Res Int. 2016;2016:7193075. doi: 10.1155/2016/7193075. Epub 2016 Jan 28. Review. PubMed PMID: 26942198; PubMed Central PMCID: PMC4749789.

7. Capalbo A, Ubaldi FM, Cimadomo D, Maggiulli R, Patassini C, Dusi L, Sanges F, Buffo L, Venturella R, Rienzi L. Consistent and reproducible outcomes of blastocyst biopsy and aneuploidy screening across different biopsy practitioners: a multicentre study involving 2586 embryo biopsies. Hum Reprod. 2016 Jan;31(1):199-208. doi: 10.1093/humrep/dev294. Epub 2015 Dec 4. PubMed PMID: 26637492; PubMed Central PMCID: PMC4677968.

6. Capalbo A, Ubaldi FM, Cimadomo D, Noli L, Khalaf Y, Farcomeni A, Ilic D, Rienzi L. MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells and can be explored for human embryo reproductive competence assessment. Fertil Steril. 2016 Jan;105(1):225-35.e1-3. doi: 10.1016/j.fertnstert.2015.09.014. Epub 2015 Oct 9. PubMed PMID: 26453979.


5. Ubaldi FM, Capalbo A, Colamaria S, Ferrero S, Maggiulli R, Vajta G, Sapienza F, Cimadomo D, Giuliani M, Gravotta E, Vaiarelli A, Rienzi L. Reduction of multiple pregnancies in the advanced maternal age population after implementation of an elective single embryo transfer policy coupled with enhanced embryo selection: pre- and post-intervention study. Hum Reprod. 2015 Sep;30(9):2097-106. doi: 10.1093/humrep/dev159. Epub 2015 Jul 5. PubMed PMID: 26150408; PubMed Central PMCID: PMC4542718.

4. Ottolini CS, Newnham L, Capalbo A, Natesan SA, Joshi HA, Cimadomo D, Griffin DK, Sage K, Summers MC, Thornhill AR, Housworth E, Herbert AD, Rienzi L, Ubaldi FM, Handyside AH, Hoffmann ER. Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates. Nat Genet. 2015 Jul;47(7):727-735. doi: 10.1038/ng.3306. Epub 2015 May 18. PubMed PMID: 25985139; PubMed Central PMCID: PMC4770575.

3. Capalbo A, Treff NR, Cimadomo D, Tao X, Upham K, Ubaldi FM, Rienzi L, Scott RT Jr. Comparison of array comparative genomic hybridization and quantitative real-time PCR-based aneuploidy screening of blastocyst biopsies. Eur J Hum Genet. 2015 Jul;23(7):901-6. doi: 10.1038/ejhg.2014.222. Epub 2014 Oct 29. PubMed PMID: 25351780; PubMed Central PMCID: PMC4463508.


2. Capalbo A, Rienzi L, Cimadomo D, Maggiulli R, Elliott T, Wright G, Nagy ZP, Ubaldi FM. Correlation between standard blastocyst morphology, euploidy and implantation: an observational study in two centers involving 956 screened blastocysts. Hum Reprod. 2014 Jun;29(6):1173-81. doi: 10.1093/humrep/deu033. Epub 2014 Feb 26. PubMed PMID: 24578475.


1. Belli M, Cimadomo D, Merico V, Redi CA, Garagna S, Zuccotti M. The NOBOX protein becomes undetectable in developmentally competent antral and ovulated oocytes. Int J Dev Biol. 2013; 57(1):35-9. doi: 10.1387/ijdb.120125mz. PubMed PMID: 23585350.